Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
41000 | - |
x * 41000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylylsulfate + cholesterol | Homo sapiens | - |
adenosine 3',5'-bisphosphate + cholesterol 3-sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BEL-7402 cell | - |
Homo sapiens | - |
HEP-3B cell | - |
Homo sapiens | - |
HEPA 1-6 cell | - |
Homo sapiens | - |
hepatocarcinoma cell | - |
Homo sapiens | - |
Huh-7 cell | - |
Homo sapiens | - |
SMMC-7721 cell | highest expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylylsulfate + cholesterol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + cholesterol 3-sulfate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 41000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
hydroxysteroid sulfotransferase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | inhibition of SULT2B1b expression induces cell-cycle arrest and apoptosis in Hepa1-6 cells by upregulating the expression of FAS, downregulating the expression of cyclinB1, BCL2 and MYC in vitro and in vivo at both the transcript and protein levels. Knock-down of SULT2B1b expression significantly suppresses tumor growth in nude mouse xenografts | down |
Homo sapiens | SULT2B1 is comparatively higher in the human hepatocarcinoma tumorous tissues than their adjacent tissues | up |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of SULT2B1 in Hepa1-6 cells induces cell-cycle arrest and apoptosis and suppresses tumorigenesis in vivo | Homo sapiens |
physiological function | SULT2B1b expression promotes proliferation of hepatocellular carcinoma cells in vitro and in vivo, which may contribute to the progression of hepatocellular carcinoma | Homo sapiens |